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| Physical Characters and Index |
Boiling point: 386.8 ± 52.0 °C (Predicted)
Density: 1.30 ± 0.1 g/cm³ (Predicted)
Form: Solid
Acidity coefficient (pKa): 0.77 ± 0.50 (Predicted)
Color: Light yellow to yellow |
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| Use and description |
| CAD031 is an orally active AMPK/ACC1 signaling pathway activator and a derivative of the Alzheimer’s disease (AD) targeted agent J147 (HY-13779) (more active than J147 in human neural stem cell assays). CAD031 can cross the blood-brain barrier, activate AMPK and inhibit ACC1, thereby increasing ac-CoA levels, improving mitochondrial function and reducing free fatty acid synthesis. CAD031 has neuroprotective, neurogenesis-promoting and memory-improving activities and can be used in the study of Alzheimer’s disease and aging-related neurodegenerative diseases. CAD031 effectively enhances the memory of mice, improves dendritic structure, and stimulates cell division in the germinal zone of the brain of elderly mice |
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