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| Physical Characters and Index |
Storage: −20°C
Form:Solid
Water solubility: Soluble to 1 mg/ml in water |
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| Use and description |
| GIP, also known as gastric inhibitory polypeptide, or glucose-dependent insu linotropic polypeptide, is a 42-amino-acid peptide hormone synthesized in and secreted from K cells in the intestinal epithelium. There are two major GIP molecular forms in circulation, GIP (1-42) and GIP(3-42). Previous studies have demonstrated that GIP (3-42) is a degraded form of GIP (1-42) by the enzyme DPPIV. GIP secretion is primarily regulated by nutrients, especially fat. GIP exhibits potent incretin activity in rodent and human subjects. The primary action of GIP is the stimulation of glucose-dependent insu lin secretion. GIP may also play a role in adipocyte biology. |
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